Want to Remain Hormonally Healthy? You Need Healthy Mitochondria!

As has been discussed many times in our blog, the modifications your body makes to estrogen after it's produced (i.e. its metabolism) can determine whether it is "friendly" or "unfriendly", i.e. protective or problematic.

DIM (diindolylmethane) promotes desirable (friendly) estrogen metabolism, and as such can reduce inflammation and thereby help all sorts of estrogen/sex hormone related issues, from reduction in risk of breast cancer, to brain performance, to hot flashes. [1] [2] (For more info see the references below). 


Yet, did you know that the primary site where sex hormones are made, whether in the gonads, adrenal glands or brain is in the mitochondria? [3] This includes estrogen! [3] As we have reviewed countless times, inflammation interferes with mitochondrial function. This reduces our energy production, as happens when we are sick, but it can also have a directly negative impact on hormone production. [4] [5] Just think, how "frisky" did you feel the last time you came down with a viral illness?


Conversely, it is also true that estrogens and their metabolites (or lack thereof), can have a big impact - either positive or negative - on mitochondrial function. [6][7][8] This can show-up, for example, in a person's brain function. Optimal cognitive performance is extremely dependent on mitochondrial function, and also highly dependent on the actions of estrogen. [9]

So what's the take-home message to maintain hormonal, cognitive, and virtually all aspects of health? The same as we have been saying for decades: if you want to remain hormonally healthy, you need healthy mitochondria.


How do you keep your mitochondria strong and healthy? I recommend Cell Fuel for both men and women. It helps optimize cellular energy production and mitochondrial function. When taken with DIM to ensure your sex-hormone related metabolism is balanced, the health benefits can be dramatic!


Read my other blogs related to this topic:


Be Well!




  1. https://www.sciencedirect.com/science/article/pii/S0147651320315906 
  2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740355/ 
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8554460/ 
  4. https://link.springer.com/article/10.1007/s10863-017-9704-1
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014424/ 
  6. https://www.sciencedirect.com/science/article/pii/S0167488909001670?via%3Dihub
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2593138/ 
  8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7212490/
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985492/   https://211377.hubspotpreview-na1.com/_hcms/preview/content/5553316764?portalId=211377&_preview=true&from_buffer=false&preview_key=qwbaxGVE

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