It would be perfectly understandable if every time you heard the word “antioxidant”, it brought to mind common nutrients like vitamin C and vitamin E. After all, those are readily found, valuable nutrients. But glutathione, even though its name doesn’t exactly roll off the tongue, very likely surpasses them all. In fact, it is so important that our bodies naturally synthesize glutathione from glycine, cysteine, and glutamic acid.(1)
Glutathione is critical for a variety of reasons: it helps fight free radicals† and reduce oxidative damage.† No wonder we make our own.(1,2)
But the aging process can take a significant toll on our natural glutathione production. By age 40, we are making 30 percent less, and by age 65, perhaps 50 percent less – and those averages are for healthy individuals.(3) Factor in aging, environmental conditions, and family history, and those numbers could drop even further. Supplementing to improve those levels seems like an obvious solution – but that too, presents its own challenges.
Supporting Glutathione Levels and Ratios – The Challenge of Supplementation
Research has found that in a state of good health, the ratio of active cellular glutathione (GSH) may be up to 98 percent with only about two percent or so making up the rest as oxidized glutathione (GSSG). (4)
When that ratio begins to tilt in the direction of oxidized glutathione, it can be an indicator of serious oxidative stress.(2, 5, 6) So supporting a healthy ratio of GSH to GSSG is key. And that’s where a sublingual form of glutathione, available as Clinical Glutathione™ from Terry Naturally® Canada, can help. It effectively delivers glutathione combined with protective antioxidants in a tablet that dissolves under the tongue.
So why not simply swallow a tablet or drink a liquid (liposomal) supplement?
Because glutathione that is swallowed, whether in tablet or liquid form, may not survive oxidation – damage by free radicals – during the digestive process unless it is specifically formulated and protected. That is why the formulation and patented process of Clinical Glutathione is important. It’s a sublingual tablet that allows the glutathione to provide optimal benefits without oxidizing and adding to the overall burden of free radicals in the body. After all, free radicals are what we’re all trying to avoid – we don’t need to add more.
The tissues beneath the tongue are rich in capillaries that can transport the glutathione directly into the blood stream as the tablet melts, allowing it to bypass the digestive tract and inevitable oxidation. Research bears out this method, too: a clinical study found that this formulation significantly supported ratios of active glutathione – GSH – to oxidized glutathione – GSSG.*(2) This is what makes it a very different kind of supplement.
The Most Important Antioxidant You’ll Ever Take
Antioxidants seem common these days because we are more aware of their presence in fruits, vegetables, and other whole foods. And without a doubt, getting antioxidants from a healthy diet is absolutely the right way to go. But if you want to go that extra step and support healthy levels and ratios of active glutathione, Clinical Glutathione is an excellent choice. It delivers effective protection against free radical damage† in a clinically studied form like no other, potentially making it the most important supplemental antioxidant you’ll ever take.
† Provides antioxidants that help protect cells against the oxidative damage caused by free radicals.
†Increases blood/plasma levels of glutathione (GSH), an antioxidant that helps fight against the oxidative damage caused by free radicals.
*Distributed in Canada by Terry Naturally CANADA, a Canadian company.
To be sure this product is right for you, always read and follow the label.
- Forman HJ, Zhang H, Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009 Feb-Apr;30(1-2):1-12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696075/
- Schmitt B, Vicenzi M, Garrel C, Denis FM. Effects of N-acetylcysteine, oral glutathione (GSH) and a novel sublingual form of GSH on oxidative stress markers: A comparative crossover study. Redox Biol. 2015 Dec;6:198-205. doi: 10.1016/j.redox.2015.07.012. Epub 2015 Jul 29. PMID: 26262996; PMCID: PMC4536296. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536296/
- Effects of N-acetylcysteine, oral glutathione (GSH), and a novel sublingual form of GSH on oxidative stress markers: a comparative study. Centre d'Enseignement et de Recherche en Nutrition (CERNh). Conducted at Centre Hospitalier de Bretagne Sud, Lorient, France. Abstract Summary, March 2013.
- Owen JB, Butterfield DA. Measurement of oxidized/reduced glutathione ratio. Methods Mol Biol. 2010;648:269-77. doi: 10.1007/978-1-60761-756-3_18. PMID: 20700719.
- Fraternale A, Paoletti MF, Casabianca A, Nencioni L, Garaci E, Palamara AT, Magnani M. GSH and analogs in antiviral therapy. Mol Aspects Med. 2009 Feb-Apr;30(1-2):99-110. doi: 10.1016/j.mam.2008.09.001. Epub 2008 Sep 27. PMID: 18926849.
- Acevedo-León D, Monzó-Beltrán L, Gómez-Abril SÁ, et al. The Effectiveness of Glutathione Redox Status as a Possible Tumor Marker in Colorectal Cancer. Int J Mol Sci. 2021 Jun 8;22(12):6183. doi: 10.3390/ijms22126183. PMID: 34201191; PMCID: PMC8226858. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8226858/